The Large-Scale Structure of Inductive Inference investigates the relations of inductive support on the large scale, among the totality of facts comprising a science or science in general. These relations form a massively entangled, non-hierarchical structure which is discovered by making hypotheses provisionally that are later supported by facts drawn from the entirety of the science. What results is a benignly circular, self-supporting inductive structure in which universal rules are not employed, the classical Humean problem cannot be formulated and analogous regress arguments fail.